Defining and Defeating the Intolerable Burden of Malaria III: Progress and Perspectives: Supplement to Volume 77(6) of American Journal of Tropical Medicine and Hygiene.

Artemisinin-based combination treatments (ACTs) are now generally accepted as the best treatments for uncomplicated falciparum malaria. They are rapidly and reliably effective. Efficacy is determined by the drug partnering the artemisinin derivative and, for artesunate–mefloquine, artemether–lumefantrine, and dihydroartemisinin–piperaquine, this usually exceeds 95%. Artesunate–sulfadoxine–pyrimethamine and artesunate–amodiaquine are effective in some areas, but in other areas resistance to the partner precludes their use. There is still uncertainty over the safety of artemisinin derivatives in the first trimester of pregnancy, when they should not be used unless there are no effective alternatives. Otherwise, except for occasional hypersensitivity reactions, the artemisinin derivatives are safe and remarkably well tolerated. The adverse effect profiles of the artemisinin-based combination treatments are determined by the partner drug. Most malaria endemic countries have now adopted artemisinin-based combination treatments as first-line treatment of falciparum malaria, but in most of these only a minority of the patients that need artemisinin-based combination treatments actually receive them.

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A Retrospective Overview of Factors that Influence Guinea Worm Epidemic in Northern Region of Ghana

This article retrospectively examines the factors which caused Guinea Worm Disease (Dracunculiasis) to spread to epidemic levels, so as to serve as the basis for formulating a national preventive agenda to reinforce the preventive measures which have been put in place to prevent the disease from re-emerging. The hybrid conceptual framework of disease diffusion and disease ecology was used. The mixed method research design was used to collect data from a total of 11 administrative districts. Primary data was obtained from a total of 860 respondents. To achieve a representative distribution of respondents, they were proportionately selected with respect to the populations of their respective districts. A key Informant interview was conducted. Download the full article for free here!

Carbon catch-22 : the pollution in our soil Bad behaviour doesn’t usually have good consequences but our fossil fuel and fertiliser habits may have had some “good” environmental side-effects. Our new research suggests that the last 200 years of pollution have increased the carbon stored in soils across natural ecosystems in Britain. And this locking in of carbon in soils provides an offset for some of our carbon emissions. But the catch-22 is if we kick our polluting habits, this carbon is at risk of returning to our atmosphere, contributing to climate change. Read the rest of the article here!

Climate crisis could reverse progress in achieving gender equality

People who directly depend on the natural world for their livelihoods, like farmers and fishers, will be among the greatest victims of the climate crisis. In vulnerable hotspots, such as the arid lands of Kenya and Ethiopia, farming communities are already struggling with droughts and water scarcity that kill their cattle and threaten their very survival. The glacial-fed river basins of the Himalayan mountains, or the deltas of Bangladesh, India and Ghana, are increasingly prone to floods, landslides and powerful cyclones. As a result, men are often migrating further to keep their families going, looking for casual work in neighbouring towns or villages for a few days or weeks at a time, or to cities further away. Many try to return home when they can, with whatever they have earned. But during their absence, the entire burden of maintaining the family is on women. Read the full article here!

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